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肠道微生物群:为精神分裂症患者心血管疾病的高患病率做出贡献?
Chuanwen Fu1, Xuehui Zhang1, Ying Qian1
1Yunnan Provincial Key Laboratory of Public Health and Biosafety & School of Public Health, Kunming Medical University, Kunming, China.
精神分裂症 (SCZ) 患者由于肠道细菌的变化,心血管疾病 (CVD) 风险更高. 在SCZ患者中,有益细菌减少和有害细菌增加可能导致心血管疾病的发展.
科学领域:
- 微生物组研究的研究.
- 精神疾病 精神疾病
- 心血管健康的心血管健康
背景情况:
- 精神分裂症 (PLWS) 患者的预期寿命缩短,心血管疾病 (CVD) 是主要原因.
- 肠道微生物群组成的变化越来越多地被认为是各种健康状况的潜在因素.
研究的目的:
- 审查PLWS中关于肠道微生物组的现有人口和动物研究.
- 为了确定与PLWS中心血管疾病风险增加相关的特定微生物变化.
- 探索将肠道失调与SCZ和CVD联系起来的潜在机制.
主要方法:
- 基于人口的研究的文献综述.
- 关于SCZ和肠道微生物群的动物模型研究的分析.
- 综合关于微生物丰富度及其与SCZ和CVD的关系的发现.
主要成果:
- 在PLWS中观察到有益细菌的数量减少,包括Lachnospiraceae,Bacteroides,Faecalibacterium,Ruminococcus,Roseburia,Bifidobacterium,Lactobacillus,Akkermansia和Rikenellaceae等.
- 在PLWS中发现了潜在有害细菌属如Prevotella,Clostridium和Escherichia的大量增加.
- 假设这些微生物的转变会影响涉及SCZ和CVD病变的物质的新陈代谢.
结论:
- 由细菌种群的具体减少和增加而特征的肠道失生症是PLWS中心血管疾病风险升高的可能因素.
- 准肠道微生物群可能为精神分裂症患者的心血管疾病管理提供新的治疗策略.
- 需要进一步的研究来阐明精确的代谢途径,将肠道微生物群的改变与SCZ和CVD发展联系起来.
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