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瘤微环境对乳腺癌中新辅助疗法的反应:从单细胞和空间奥米克的见解

Qingzhong Wu¹, Jiawei Yang¹, Da Zhang¹

¹The Clinical Medical College, Guizhou Medical University, Guiyang, 550004, Guizhou Province, China.

Medical oncology (Northwood, London, England)

|September 13, 2025

概括

新辅助疗法重塑了乳腺癌的治疗方法. 本综述探讨了像单细胞分析这样的先进分子技术如何在治疗期间揭示瘤微环境 (TME) 变化,这对于理解治疗反应至关重要.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症研究癌症研究

背景情况:

乳腺癌是一个主要的公共卫生问题.
新辅助疗法改变了乳腺癌的治疗方法.
瘤微环境 (TME) 显著影响瘤进展和治疗结果.

研究的目的:

审查乳腺癌新辅助疗法的现状.
概述研究乳腺癌TME的先进分子研究方法.
在新辅助治疗期间总结TME变化,强调单细胞和空间分析.

主要方法:

对新辅助疗法当前文献的综述.
讨论单细胞分析技术.
在癌症研究中探索空间奥米克技术.

主要成果:

新辅助疗法是乳腺癌治疗的关键策略.
单单细胞和空间奥米克提供了对TME复杂性的深入洞察.
了解TME动态对于预测治疗反应至关重要.

结论:

先进的分子技术正在彻底改变乳腺癌TME研究.
在新辅助治疗期间调查TME变化对于改善患者的治疗结果至关重要.
本综述强调了TME特征在个性化乳腺癌治疗中的重要性.

关键词:

乳腺癌是什么? 乳腺癌是什么一个单细胞分析.空间奥米克斯空间奥米克斯瘤微环境是一个微环境.

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The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...