探索药物诱导睡眠内镜在优化上呼吸道刺激疗法对不响应者的作用
E Kant1,2,3, J A Hardeman4, R J Stokroos5,6
1Department of Otorhinolaryngology Head and Neck Surgery, Sint Antonius Hospital, Nieuwegein, the Netherlands. E.kant@umcutrecht.nl.
Sleep & breathing = Schlaf & Atmung
|September 13, 2025
概括
药物诱导的睡眠内镜有助于低分泌神经刺激阻塞性睡眠呼吸暂停 (OSA) 治疗. 这一程序有助于确定非响应者的最佳设置或额外疗法,改善治疗结果.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 睡眠医学 睡眠医学
- 生物医学工程 生物医学工程
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 影响着数百万人,低分泌神经刺激 (HNS) 为CPAP提供了替代方案.
- 一些患者对标准的HNS定位方法没有反应.
- 识别HNS故障的原因对于有效的OSA管理至关重要.
研究的目的:
- 评估药物诱导睡眠内镜 (DISE) 结合上呼吸道刺激 (UAS) 在非响应性OSA患者中的实用性.
- 评估DISE指导的修改UAS设置和额外疗法的影响.
- 报告患者在这种结合诊断和治疗方法后的结果.
主要方法:
- 在2015年至2022年期间接受UAS植入的患者的回顾性图表审查.
- 在29名没有反应者身上进行了DISE,以评估睡眠期间的上呼吸道崩.
- 基于DISE发现的无人机设备设置变化的分析和额外疗法的实施.
主要成果:
- DISE确定了7名患者,仅使用UAS设置调整就有所改善.
- 14名患者在DISE后需要额外的治疗 (口腔器械,手术).
- 干预后,呼吸暂停-呼吸暂停指数显著下降,从每小时41.6事件降至23.2事件.
- 另外8名患者对HNS疗法产生了反应.
结论:
- DISE是在OSA的HNS临床途径中是一个有价值的工具.
- 它增强了对UAS刺激过程的评估.
- DISE促进了优化设备设置和针对性的额外疗法,以改善患者的治疗结果.
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