探索药物耐药性中的代谢生物标志物和途径:系统性审查
Zheng-Dong Lim1, Nur Asyiqin Syafiqa Abdullah1, Kheng-Seang Lim2
1Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur 50603, Malaysia.
Epilepsy research
|September 13, 2025
概括
耐药性 (DRE) 影响了三分之一的患者. 本综述确定了关键的代谢生物标志物和途径,如氨基酸和葡萄糖代谢,为个性化DRE治疗和新药开发提供了希望.
科学领域:
- 神经科学是一个神经科学.
- 代谢学 代谢学 代谢学
- 生物化学 生物化学
背景情况:
- 耐药性 (DRE) 影响近三分之一的患者,尽管使用抗发作药物 (ASM).
- 目前的ASM在显著的患者小组中实现缓解是无效的.
- 识别可靠的生物标志物对于DRE个性化治疗策略至关重要.
研究的目的:
- 系统地审查和识别与DRE相关的潜在代谢生物标志物和途径.
- 探索这些生物标志物如何为个性化治疗方法提供信息并优化治疗结果.
- 评估代谢产物和代谢途径在DRE预测和新疗法标识中的作用.
主要方法:
- 在Medline,Web of Science和CENTRAL进行了全面的系统文献搜索.
- 根据预先定义的包含/排除标准,选择了29项符合条件的研究,并进行了全文选.
- 使用MetaboAnalyst 6.0进行识别代谢物的途径分析.
主要成果:
- 几种代谢物,包括氨基酸 (甘氨酸,谷氨酸,异氨酸),乳酸和葡萄糖,被确定为潜在的DRE生物标志物.
- 途径分析揭示了氨酸,酸盐和谷氨酸代谢的重要作用.
- 氨,氨酸和氨酸的生物合成途径也显示出与DRE.相关的显著影响.
结论:
- 已识别的代谢物和代谢途径显示为DRE.的预测生物标志物具有前途.
- 这些发现可能为管理中个性化治疗策略铺平道路.
- 已识别的途径代表了开发DRE新型治疗干预措施的潜在目标.
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