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卵巢癌中PFAS的预后关联:探索性分析的见解

Hongyu Xie¹, Danyun Wang², Liang Feng³

¹Clinical Research Center, Women's Hospital, School of Medicine Zhejiang University, Hangzhou, Zhejiang, China; Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Hangzhou, Zhejiang, China.

Ecotoxicology and environmental safety

|September 13, 2025

概括

和多醇基物质 (PFAS) 可以预测卵巢癌 (OC) 的预后. 来自PFAS的风险评分显示了识别患者结果的潜力,并为这种致命的妇科恶性瘤提供治疗策略的信息.

科学领域:

环境健康环境健康
妇科瘤学妇科瘤学
毒素基因组学毒素基因组学

背景情况:

卵巢癌 (OC) 缺乏可靠的生物标志物来预测异质的临床结果.
和多醇基物质 (PFAS) 是内分泌干扰剂,其在OC中作用尚不清楚.
这项研究调查了PFAS和OC预后之间的关联.

研究的目的:

探索PFAS作为卵巢癌预后预测生物标志物的潜力.
开发和验证OC的PFAS衍生风险评分.
研究OC中PFAS的潜在分子机制.

主要方法:

从公共数据库中获取PFAS相关的mRNA和OC表达数据.
利用考克斯回归,随机生存森林和拉索方法来确定预后因素.
构建并验证了PFAS衍生风险预测模型,用于整体生存 (OS) 和无进展生存 (PFS).
进行了分子对接和体外实验,以评估PFAS对OC细胞的影响.

主要成果:

来自PFAS的风险评分独立预测了OC预后,在验证集中具有显著的AUC值.
较低的风险得分与化疗的潜在益处相关.
分子对接表明PFAS和向蛋白质之间有很高的亲和力.
实验室研究表明, perfluorooctanoic 酸暴露促进了OC细胞恶性病变,并改变了特定的基因表达.

结论:

来自PFAS的风险评分显示了预测OC预后的潜力.
这些发现为卵巢癌的临床治疗策略提供了洞察力.
PFAS可能在卵巢癌中发挥显著的预后作用.

关键词:

卵巢癌是发生在卵巢中的癌症.总体生存率总体生存率 -和多基基物质 (PFAS) 的使用.没有进展的生存率.

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