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通过基于Au纳米集群的可逆NIR-II光探针进行急性损伤的长期动态跟踪

Qing Hu¹, Fanyi Qin¹, Huijiao Qu¹

¹Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed By the Province and Ministry, Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules & College of Chemistry and Chemical Engineering, Hubei University, Wuhan, Hubei, 430062, PR China.

Biosensors & bioelectronics

|September 13, 2025

概括

研究人员开发了一种新的近红外光探针,用于实时,长期监测急性损伤 (AKI). 该工具在体内追踪活性氧物种 (ROS),帮助早期诊断和治疗病的开发.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
医疗成像医学成像

背景情况:

急性损伤 (AKI) 是一个重大的健康挑战,早期阶段往往无症状,使及时干预复杂化.
有效的实时监测AKI进展对于早期诊断和治疗至关重要,但目前的方法有限.
很难在长时间内在体内跟踪像活性氧物种 (ROS) 这样的生物标志物.

研究的目的:

开发一种新的,可以通过清除的,可逆响应的光探针,用于长期的AKI体内监测.
为了使高分辨率的脏成像和实时跟踪AKI进展期间的氧化还原状态变化.
为AKI提供一种新的选潜在治疗药物的工具.

主要方法:

使用黄金纳米集群 (Au NCs) 构建可逆氧化第二次近红外 (NIR-II) 光探针.
在体内评估探针的NIR-II激发/发射,脏向,保留和对ROS的响应.
探针的应用用于长期动态跟踪AKI进展和氧化还原波动.

主要成果:

开发的基于Au NCs的探头表现出NIR-II光,有效的脏向和长时间的保留,用于高分辨率的脏成像.
探测器表现出对ROS的快速,敏感和选择性可逆反应,使实时的体内氧化还原监测成为可能.
探测器成功实现了前所未有的AKI进展的实时动态跟踪,提供了关键的氧化还原状态信息.

结论:

新型的NIR-II光探针提供了一个强大的工具,通过ROS跟踪来长期实时监测AKI进展.
这项技术促进了早期诊断,及时干预,以及对脏疾病的潜在新疗法策略.
该探针作为一个有效的平台来选AKI治疗剂.

关键词:

急性损伤是什么?急性损伤是什么?一个纳米集群的au.有可逆反应的反应.第二个近红外光探测器.

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