在2023-2024年韩国爆发期间,百日咳的传播动态和风险因素
Si-Ho Kim1, Hyeokjin Lee2, Yu Mi Wi1
1Division of Infectious Diseases, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea.
Vaccine
|September 13, 2025
概括
尽管接种了疫苗,百日咳仍然是一个威胁. 这项研究发现,自上次咳增剂接种疫苗和延迟诊断以来的较长时间间隔,在2023年韩国爆发期间增加了传播风险.
科学领域:
- 流行病学 流行病学
- 传染病控制和控制传染病
背景情况:
- 百日咳 (百日咳) 疫情在全球范围内持续,即使疫苗接种覆盖率高.
- 了解传播动态对于有效的控制策略至关重要.
研究的目的:
- 调查百日咳传播动态,并确定2023年韩国爆发期间的风险因素.
- 评估疫苗接种情况和诊断时间对百日咳传播的影响.
主要方法:
- 对103例实验室确诊的百日咳病例的接触追踪数据的分析.
- 多变量后勤回归用于识别传播的独立预测因素.
- 接收器操作特征 (ROC) 曲线分析以确定最佳的疫苗接种时间截止.
主要成果:
- 观察到高传染性:81.6%的病例是感染接触者,中位数的二次攻击率为26.9%.
- 传染的独立预测因素包括自上次接种疫苗以来的较长时间 (OR 1.04) 和诊断前的较长症状持续时间 (OR 1.85).
- 自上次接种疫苗以来的最佳切断时间为27个月,以预测传播.
结论:
- 百日咳具有很高的传染性,需要采取强有力的控制措施.
- 及时接种 pertussis 补充疫苗和及时诊断对于缓解疫情的爆发至关重要.
- 疫苗接种间隔和诊断延迟显著影响 pertussis 传播动态.
相关概念视频
Transmission-based Precautions II: Airborne and Protective Environment
1.8K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.8K
Transmission-based Precautions I: Contact, Enteric, and Droplets
4.5K
Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
4.5K
Steps in Outbreak Investigation
492
In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
492
Factors Affecting the Risk of Infection
13.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.3K
Pulmonary Tuberculosis I
844
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
844
Infection
11.9K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.9K


