用pH循环方法在糖/二甲基硫酸盐复合纳米囊中加载黄素,以提高酸稳定性和生物可访问性
1Department of Food Engineering, Hitit University, Çorum, Turkey; Department of Food Science, University of Tennessee, Knoxville, TN, United States.
Food chemistry
|September 13, 2025
概括
贝和二硫酸盐 (SDS) 创建稳定的纳米系统,用于库尔库的交付,即使在酸性条件下. 这种组合增强了库尔库明的作用.
科学领域:
- 食品科学与技术 食品科学与技术
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
背景情况:
- 贝菌表现出黄素传递的潜力,但在酸性环境中缺乏稳定性.
- 黄素是一种强大的生物活性化合物,需要有效的输送系统才能获得最佳的治疗用途.
- 饮料中常见的酸性状况可能会导致贝基系统的沉.
研究的目的:
- 调查二甲基硫酸盐 (SDS) 与贝的使用,以提高素载纳米系统的稳定性和酸性耐受性.
- 评估SDS对贝糖-黄素分散物的封装效率和颗粒大小的影响.
- 在模拟的胃肠道和结肠条件下,通过糖-SDS联合系统输送的黄素的生物可访问性进行评估.
主要方法:
- 在不同的pH值 (7.0,4.6,3.0) 上,制备不同度的SDS的贝糖-黄素分散剂.
- 封装效率 (EE) 和Z-平均直径的分析,以确定分散稳定性和颗粒特性.
- 在体外模拟的胃肠和结肠消化试验中测量黄素的生物可访问性.
主要成果:
- 添加SDS在pH 7.0 (高达83.7%) 时提高了封装效率,并在酸性pH 4.6 (61-70%EE) 和3.0 (60-64%EE) 时保持显著的稳定性.
- 颗粒大小 (Z-平均直径) 在pH7.0 (13-18纳米) 保持一致,并在酸性条件下随着SDS度的增加而减少 (pH4.6:50-108纳米;pH3.0:46-91纳米).
- 在模拟胃肠道消化后,黄素的生物可访问性达到32-33%,在用20 mg/mL SDS进行结肠消化后达到65%以上.
结论:
- 将糖与二硫酸盐 (SDS) 结合起来,显著提高了黄素纳米输送系统的酸性稳定性.
- 贝-SDS系统证明了黄素的提高生物可访问性,特别是在结肠消化后.
- 这种配方对在酸性食品和饮料应用中开发稳定,生物可用的黄素输送有希望.
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