在新鲜胚胎囊移植日的血清孕激素度与活产率没有相关性
An-Sofie Rottiers1, Lien Dhaenens1, Florence Vandierendonck1
1Department of Reproductive Medicine, Ghent University Hospital, Ghent, Belgium.
Reproductive biomedicine online
|September 13, 2025
概括
囊胚移植当天的血清孕激素水平不能预测受微化阴道孕激素 (MVP) 乳房支试管婴儿治疗的妇女的活产率 (LBR). 这一发现质疑用于LBR预测的孕激素测量的常规使用.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精 (IVF)
- 临床胚胎学 临床胚胎学
背景情况:
- 在试管婴儿周期中,质阶段的支持至关重要.
- 微型化阴道孕激素 (MVP) 常用于体支持.
- 转移当天血清孕激素水平在预测试管婴儿结果中的作用仍在争论中.
研究的目的:
- 调查单个新鲜胚胎细胞移植当天的血清孕激素度与活产率 (LBR) 之间的关联.
- 评估孕激素水平是否会影响其他怀孕结果,如阳性β-人类胆性腺激素 (β-HCG) 和正在进行的怀孕率.
主要方法:
- 对508个新鲜单胞胎细胞移动周期的回顾性队列研究.
- 转移当天测量血清孕激素;MVP用于质支持.
- 统计分析包括调整的赔率比率和非线性关联.
主要成果:
- 在转移当天的血清孕激素水平和LBR之间没有发现显著的关联.
- 在孕激素切断值为27 ng/ml或40 ng/ml时,LBR没有显著差异.
- 孕激素水平>40 ng/ml与阳性β-HCG的更高几率有关.
结论:
- 转移当天的血清孕激素测量可能不是MVP叶支持LBR的可靠指标.
- 常规的孕激素监测和"救援"策略可能需要重新评估.
- 需要进一步的研究,以优化黄质阶段支持协议.
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