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通过COX17传输的西斯普拉丁通过结合Myosin IIA来调节由线粒体功能障碍诱导的细胞烧亡,从而诱导耳损伤

Jiahui Peng1, Guofang Tao1, Xubo Chen1

  • 1Department of Otolaryngology Head and Neck Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.

Life sciences
|September 13, 2025
PubMed
概括

细胞染色体c氧化酶铜伴侣蛋白17 (COX17) 将西斯普拉丁运送到耳线粒体,导致听力损失. 降低COX17或Myosin IIA的调节可以保护大鼠免受西斯普拉丁诱导的耳毒性和耳损伤.

关键词:
在COX17中,COX17是最重要的.西斯普拉丁的耳毒性肌二甲酸二甲酸二甲酸线粒体损伤可能导致线粒体损伤.热灭症是什么?

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