精神分裂症的神经发育偏差:基于多模式连接体的大脑衰老的证据
Yun-Shuang Fan1, Pengfei Yang1, Yucheng Zhu1
1The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Progress in neuro-psychopharmacology & biological psychiatry
|September 13, 2025
概括
早期精神分裂症 (EOS) 患者在结构性大脑发育中表现出高级大脑年龄差距,与典型的轨迹不同. 这些偏差与症状严重程度相关,表明精神分裂症的早期发育变化.
科学领域:
- 神经成像是一种神经成像.
- 发育神经科学的发展神经科学.
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症涉及早期发育的脑部变化,可以通过MRI检测到.
- 大脑年龄估计是一种新的方法来表征这些偏差.
- 早期精神分裂症 (EOS) 的发展轨迹尚未完全理解.
研究的目的:
- 用多式核磁共振和机器学习来调查EOS中的大脑发育偏差.
- 为了评估与典型发育 (TD) 对照组相比,EOS患者的大脑年龄差距.
主要方法:
- 收集了T1w-MRI,扩散MRI和rs-fMRI数据,来自80名未服用过抗精神病药物的EOS患者和91名TD对照.
- 构建的结构连接体 (SC),形态相似性连接体 (MSC) 和功能连接体 (FC).
- 在TD数据上训练了大脑年龄模型,并在EOS患者中预测了大脑年龄,以计算大脑年龄差距.
主要成果:
- SC和MSC特征准确估计了大脑年龄;FC特征没有.
- 使用SC/MSC的EOS患者的绝对大脑年龄差距比使用TD的对照人群大.
- 大脑年龄差异在童年和青春期表现出相反的趋势,与症状严重程度相关.
结论:
- 在患有精神分裂症的年轻人中存在先进的大脑年龄差距,可以通过多模式MRI检测到.
- 这些发现凸显了EOS早期发育中断.
- 大脑年龄分析提供了对精神分裂症神经发育起源的见解.
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