同时的身体和营养干预可以减少肝硬化患者肝移植名单上的脆弱性:随机对照试验
Carlos Benítez1, Diego Reyes2, Catalina Grandy2
1Gastroenterology Department, Escuela de Medicina, Pontificia Universidad Católica de Chile, Chile.
双重运动和营养干预显著降低了等待肝移植的肝硬化患者的脆弱性. 这一策略改善了肝脏虚弱指数 (LFI),并减少了虚弱个体的比例.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 老年病的医生 老年病的医生
- 移植医学 移植医学
背景情况:
- 虚弱是肝硬化患者不良结果的重要预测因素.
- 在这个人群中,对于脆弱性没有确立的治疗策略.
- 肝移植候选人有脆弱面临增加的发病率和死亡率风险.
研究的目的:
- 为了评估运动和营养干预联合的有效性.
- 为了改善肝硬化患者的虚弱状态,肝脏移植患者列在肝脏移植名单上.
- 评估干预后肝脏脆弱指数 (LFI) 的变化.
主要方法:
- 随机对照试验与66名患者 (LFI ≥3.2).
- 干预组接受指导性炼和营养;对照组接受标准咨询.
- 12周的干预期与LFI重新评估.
主要成果:
- 干预组的LFI显著改善 (ΔLFI为0.4比0.14,p=0.02).
- 在干预组中观察到虚弱患者比例的显著减少 (28.1%与8.8%,p=0.02).
- 这项研究包括了MELD Na 17.2 ± 5和Child Pugh B/C分类的患者.
结论:
- 双重干预策略有效地减少了等待肝移植的肝硬化患者的脆弱性.
- 这种方法提供了一种有前途的方法,可以改善患者移植前的结果.
- 进一步的研究可能会探索长期益处和更广泛的适用性.
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