环境空气污染和功能指标之间的关联:全面的系统性审查和元分析
Rongrong Li1, Kai Wang1, Ming Li1
1Department of Occupational and Environmental Health, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China; Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an, China; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, Xi'an, Shaanxi, China; Key Laboratory of Trace Elements and Endemic Diseases in Ministry of Health, Xi'an, Shaanxi, China.
环境空气污染对功能产生负面影响. 暴露于PM2.5,PM10和NO2与降低估计的球过率 (eGFR) 和增加血清肌素有关.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
背景情况:
- 环境空气污染越来越被认为是慢性病 (CKD) 的重要环境风险因素.
- 功能指标对于诊断和分类病至关重要.
- 了解空气污染物与功能之间的联系对于公共健康至关重要.
研究的目的:
- 进行元分析,评估环境空气污染与关键功能指标之间的关联.
- 量化各种空气污染物对eGFR,血清肌素和BUN等标记物的影响.
主要方法:
- 在PubMed,Web of Science,Scopus和Embase进行了全面的文献搜索,截至2024年9月27日.
- 包括的研究报告了环境颗粒物 (PM1,PM2.5,PM10),NO2,O3,SO2,CO和功能指标 (eGFR,SCr,BUN,UA,CysC) 之间的关联.
- 分析包括32项研究,涉及300多万成年参与者.
主要成果:
- 长期暴露于PM2.5,PM10和NO2与降低EGFR有关.
- 长期暴露于PM2.5与血清肌素 (SCr) 和尿酸 (UA) 的升高有关.
- 短期的PM2.5暴露与较低的eGFR和较高的血尿素 (BUN) 相关.
结论:
- 环境空气污染对功能构成有害的风险.
- 像PM2.5,PM10和NO2这样的特定污染物显示出与脏指标受损的显著关联.
- 进一步的研究和公共卫生干预是有必要的,以减轻空气污染对脏健康的影响.
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