维生素D/胰岛素比率与女孩中部早期青春期之间的相关性及其查潜力
Jun Sun1, Ya Xiao1, Shu-Qin Jiang1
1Department of Pediatric Endocrinology and Genetic Metabolism, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
Anales de pediatria
|September 13, 2025
概括
维生素D/胰岛素比率 (VDIR) 可能有助于选女孩中部早期青春期 (CPP). 较低的VDIR与增加的CPP风险和较小的子宫体积有关,这表明其作为一种新生物标志物的潜力.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 代谢生物标志物 代谢生物标志物
- 青春期发展 青春期发展
背景情况:
- 缺乏有效的生物标志物来诊断中部早期青春期 (CPP).
- 像维生素D或胰岛素这样的个体代谢指标容易受到干扰.
- 评估维生素D/胰岛素比率 (VDIR) 可能提供一个更可靠的指标.
研究的目的:
- 评估维生素D/胰岛素比率 (VDIR) 和CPP之间的相关性.
- 评估VDIR作为CPP选工具的潜力.
- 调查VDIR与生殖腺发育指标的关联.
主要方法:
- 一项涉及170名6-10岁女孩 (85名CPP,85名对照) 的病例控制研究.
- 收集生长,发育和实验室数据,包括维生素D和胰岛素水平.
- 多变量逻辑/线性回归和ROC曲线分析,以评估VDIR的关联和诊断价值.
主要成果:
- 与对照组 (6.18) 相比,患有CPP的女孩 (3.45) 的VDIR显著较低.
- VDIR显示CPP的诊断AUC (0.731) 比单独维生素D或胰岛素更高.
- 增加的VDIR与降低的CPP风险和减少的子宫体积相关.
结论:
- 通过整合维生素D和胰岛素相互作用,VDIR显示出作为CPP风险评估的生物标志物具有前途.
- VDIR可能有助于早期查高风险人群的CPP.
- 这个比率可以指导针对CPP管理的个性化干预.
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