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Updated: Jan 17, 2026

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在肺腺癌中,KRAS突变通过ETV4促进PD-L1介导的免疫逃脱

Daqi Jia1, Peng Wang1, Shiqi Zheng1

  • 1Department of Pathology, 920th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Kunming, Yunnan, China.

Translational oncology
|September 14, 2025
PubMed
概括

肺腺癌中的KRAS突变通过MEK-ERK-ETV4通路增加PD-L1的表达. 这种机制驱动免疫逃生,为肺癌提供潜在的治疗点.

关键词:
在 ETV4 上播放.豁免权的逃逸 豁免权的逃逸在KRAS突变中发生突变.在NSCLCLC中,我们可以看到.在PD-L1中.

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