素改善皮肤脂质过分分泌,炎症和氧化应激 in vivo 和 in vitro

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Updated: May 3, 2026

Quantification of Hypopigmentation Activity In Vitro

Quantification of Hypopigmentation Activity In Vitro

Published on: March 6, 2019

Jie Li¹, Bingyong Mao¹, Botao Wang²

¹State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, China; School of Food Science and Technology, Jiangnan University, Wuxi, China.

The Journal of nutritional biochemistry

|September 14, 2025

概括

素 (LUT) 有效地降低了皮肤脂质积累和胆固醇水平. 这种天然化合物也对肠道细菌产生积极影响,并减少炎症,这表明对皮肤健康有好处.

科学领域:

生物化学生物化学
皮肤病学皮肤病学
微生物学微生物学

背景情况:

素 (LUT) 是一种具有多种生物活性的天然化合物,包括在皮肤健康中的应用.
过度的皮肤脂质产生是一种常见的疾病,会影响小底腺,特别是在青少年中.

研究的目的:

为了研究素 (LUT) 在减轻油酸 (OA) 诱导的皮肤脂质积累方面的疗效.
评估LUT对脂质代谢标记物,肠道微生物群和皮肤炎症通路的影响.

主要方法:

使用C57BL/6小鼠进行了体内研究,使用SZ95细胞进行了体内研究.
评估的甘油三 (TG),非化脂肪酸 (NEFA) 和胆固醇水平.
分析了肠道细菌的多样性,炎症标志物 (TNF-α,IL-6),脂质过氧化 (MDA) 和SIRT1的表达.

主要成果:

氨酸在体内显著降低胆固醇水平,在体内显著降低TG和NEFA水平.
LUT调节了肠道细菌的多样性,增加了诸如阿克尔曼西亚,细菌类和Alistipes等有益的属.
LUT降低了马隆迪甲基 (MDA) 和促炎因素 (TNF-α,IL-6),同时对SIRT1mRNA进行了上调.

结论:

氨酸在改善皮肤脂质积累方面表现出显著的潜力.
LUT的抗炎和抗氧化作用可能与SIRT1通路激活有关.
LUT对肠道微生物群的积极调节表明,LUT在整体皮肤健康维护中发挥了作用.

关键词:

炎症炎症是一种炎症.肠道的微生物群.卢特奥林是什么意思?卢特奥林是什么意思?氧化应激是一种氧化应激.皮肤脂质是皮肤的脂质.

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