基于FAERS和VigiBase数据库的免疫检查点抑制剂相关的肺部不良事件分析
Zi-Mu Li1, Yi-Fan Zheng2, Pei-Hang Xu3
1Division of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Institute of Pulmonary Diseases, Sun Yat-sen University, Guangzhou, China; Division of Pulmonary and Critical Care Medicine, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
免疫检查点抑制剂 (ICI) 的肺免疫相关不良事件 (pirAEs) 经常在60天内发生,死亡率更高. 早期识别像间歇性肺病这样的pirAEs对于患者的治疗结果至关重要.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 已经彻底改变了癌症治疗.
- 肺免疫相关不良事件 (pirAEs) 是ICI治疗的严重并发症.
- 了解pirAEs的时间模式和死亡率对于临床管理至关重要.
研究的目的:
- 调查与ICI相关的pirAEs的发生率,类型和死亡率.
- 分析ICI启动后在特定时间框架内发生的pirAEs.
- 根据pirAEs的早期发现和管理策略提供信息.
主要方法:
- 从FDA不良事件报告系统 (FAERS) 和世卫组织VigiBase中分析个体病例安全报告 (ICSR).
- 数据收集范围从2015年第一季度到2020年第二季度.
- 基于ICI启动后的时间对pirAE发病率和死亡率的评估.
主要成果:
- 超过50%的pirAEs发生在ICI治疗60天内,与晚期事件相比死亡率更高.
- 常见的pirAEs包括间歇性肺病,呼吸障碍和肺炎.
- 呼吸衰竭,肺出血,急性间歇性肺炎和杆炎的高死亡率 (> 25%) 被观察到,即使在一年后,呼吸衰竭死亡率仍然很高 (> 40%).
结论:
- 在ICI治疗后的最初60天是pirAEs的高风险时期.
- 在早期治疗期间,医生应警特定的pirAEs,特别是间歇性肺病和肺炎.
- 及时识别和干预对于改善pirAEs患者的治疗结果至关重要.
更多相关视频
10:18Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction
Published on: July 7, 2023
06:07Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood
Published on: February 5, 2020
相关概念视频
Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Therapeutic Drug Monitoring: Affecting Factors
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
