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相关概念视频

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Papillary Dermis01:11

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Reticular Dermis01:15

Reticular Dermis

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
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Nephrotic Syndrome II : Assessment and Medical Management01:26

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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Autoimmune Disorders01:29

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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在prurigo nodularis中的并发症

Jaya Manjunath1, Brenda Umenita Akinniyi1, Alexander L Kollhoff1

  • 1Department of Dermatology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

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概括

发结节 (PN) 是一种慢性炎症性皮肤疾病,引起强烈的和结节. 它的管理需要解决对生活质量和许多相关健康状况的重大影响.

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科学领域:

  • 皮肤病学 皮肤病学
  • 免疫学 免疫学 免疫学
  • 神经学 神经学

背景情况:

  • 节炎 (prurigo nodularis,简称PN) 是一种慢性炎症性皮肤疾病,主要表现为严重的和超质结节.
  • 它的致病性涉及复杂的神经免疫失调与炎症性细胞因子和神经.
  • 延迟性会大大降低患者的生活质量,比其他慢性性疾病更严重.

研究的目的:

  • 要总结目前对 Prurigo nodularis 病原体,临床表现和管理的理解.
  • 突出PN对患者生活质量的重大影响.
  • 强调识别和管理与PN相关的并发症的重要性.

主要方法:

  • 综述了关于 Prurigo nodularis 的现有文献.
  • 分析神经免疫通路在PN中的作用.
  • 评估与PN相关的全身和精神病并发症.
  • 评估当前和新兴的治疗策略.

主要成果:

  • PN的发病包括神经免疫失调和炎症介导体.
  • 患有PN的患者经历了更大的疾病严重程度,的强度和生活质量的降低.
  • 脑膜炎与众多系统性并发症 (例如,CKD,心血管疾病,HIV) 和精神疾病 (例如,抑郁症,焦虑症) 有关.
  • 神经病的并发症,如神经病痛和睡眠障碍也很普遍.

结论:

  • 对伴随性疾病的全面评估对于个性化PN管理至关重要.
  • 治疗的目的是缓解和改善生活质量,利用免疫抑制剂,神经调节剂或生物药物,如dupilumab.
  • 进一步研究PN病原和向治疗是有必要的.