药物诱导的急性管介质炎:关于诊断和治疗的当前观点
Javier Azores-Moreno1, Clara Cases-Corona2, Beatriz Sánchez-Álamo3
1Department of Nephrology, Hospital Universitario La Paz, Instituto de investigación de la Paz (IdIPAZ), Madrid, Spain.
Advances in kidney disease and health
|September 14, 2025
概括
急性管间炎 (ATIN) 导致急性损伤 (AKI),并可能导致慢性病. 早期诊断和治疗,包括停止治疗原因和使用皮质类固醇,对于保持功能至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内部医学 内部医学
- 病理学 病理学 病理学
背景情况:
- 急性管间炎 (ATIN) 是急性损伤 (AKI) 的主要原因,占活检证明病例的15-27% .
- 虽然一些患者康复了,但很大一部分患者可能会患上慢性病或需要透析.
- 药物诱导的ATIN是最常见的,与NSAID,抗生素和PPI有关,感染和自身免疫性疾病是较少的原因.
研究的目的:
- 要总结急性管间炎 (ATIN) 的关键方面.
- 要突出诊断标准和ATIN的临床表现.
- 讨论ATIN目前的治疗策略.
主要方法:
- 关于急性管间炎 (ATIN) 的现有文献的综述.
- 对临床表现,诊断结果和治疗结果的分析.
- 强调脏活检的发现,以确定确诊.
主要成果:
- ATIN表现出各种症状,从无症状的AKI到全身症状,如发烧,皮疹和eosinophilia.
- 尿液分析可能会显示无菌性皮尿,血尿和白血细胞体,通常是轻微的蛋白尿.
- 脏活检是确定的,显示了间歇性透,胀和管道损伤.
结论:
- 及时识别和管理ATIN对于预防不可逆转的损伤至关重要.
- 目前的治疗重点是停止侵扰剂,支持性护理和皮质类固醇治疗.
- 对ATIN的最佳治疗策略需要进一步描述.
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