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诊断急性管间疾病的临床工具

Abinet M Aklilu¹, Anusha Sundararajan²

¹Section of Nephrology, Yale School of Medicine, New Haven, CT; Clinical and Translational Research Accelerator, New Haven, CT.

Advances in kidney disease and health

|September 14, 2025

概括

急性管间炎 (ATIN) 是急性损伤 (AKI) 的常见原因之一. 本综述强调了诊断挑战和目前的证据,以识别ATIN,这对于及时管理和预防慢性病至关重要.

科学领域:

腎臟病學 (nephrology) 是一種醫學.
病理学病理学病理学
在瘤学瘤学.

背景情况:

急性管间炎 (ATIN) 是急性损伤 (AKI) 的重要原因,在高达25%的活检中发现了AKI.
药物诱导的ATIN,特别是来自抗生素,是常见的,与癌症治疗中的质子抑制剂和免疫检查点抑制剂相关的发病率上升.
由于ATIN的发病时间变化,非特异性症状以及缺乏标准化的诊断标准,延迟诊断是常见的,可能导致慢性病.

研究的目的:

审查目前关于诊断ATIN的证据,重点关注临床,实验室和成像发现.
解决ATIN的诊断挑战,特别是在瘤治疗的背景下将其与其他AKI原因区分开来.
强调需要准确的诊断工具来指导治疗和预测患者的反应.

主要方法:

审查关于ATIN诊断的现有文献.
分析与ATIN相关的临床,实验室和成像发现.
讨论诊断挑战和未满足的需求,特别是与瘤治疗相关的AKI.

主要成果:

鉴于ATIN的发病时间和非特异性临床表现的变化,诊断更加复杂.
脏活检仍然是黄金标准,但缺乏标准化的标准.
目前的诊断工具难以区分ATIN的原因和预测治疗反应,特别是在复杂的病例中,如瘤治疗相关的AKI.

结论:

准确及时诊断ATIN对于预防慢性病进展至关重要.
需要改进的诊断策略来区分ATIN与其他AKI病因,特别是在接受瘤治疗的患者中.
对可靠的诊断标记和工具的进一步研究对于最佳的患者管理至关重要.

关键词:

一个AININ一个AIN 在 ATIN 中,您可以使用 ATIN.急性损伤是什么?急性损伤是什么?诊断工具诊断工具诊断工具输卵管间歇性疾病输卵管间歇性疾病

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