理想的食纤维模型:基于结构功能关系的个性化肠道微生物群调制.
Chengming Wang1, Shining Qin1, Jiaqi Shi1
1Key Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, Department of Animal Science, Shandong Agricultural University, Taian, Shandong 271017, China.
Carbohydrate polymers
|September 14, 2025
概括
理想的食纤维模型通过根据结构量身定制纤维配方来提出个性化的肠道健康方法. 该框架旨在精确调节肠道微生物和代谢物,以改善宿主生理学.
科学领域:
- 微生物组研究的研究.
- 营养科学 营养科学
- 个性化医疗是个性化的医疗.
背景情况:
- 食纤维显著影响肠道微生物群和宿主健康.
- 目前的纤维分类对于有针对性的微生物调制缺乏精度.
- 了解纤维-微生物群相互作用对于各种疾病至关重要.
研究的目的:
- 介绍"理想的食纤维模型",用于个性化的肠道微生物生态系统设计.
- 强调结构引导的纤维配方,以精确调节微生物群.
- 综合有关疾病中纤维微生物群相互作用的当前知识.
主要方法:
- 专注于结构参数:单糖化合物组成,糖链接和聚合度.
- 为选择性微生物调制和代谢物生产突出显示寡糖类.
- 审查疾病中纤维微生物群相互作用的临床前和临床证据.
主要成果:
- 纤维结构决定了微生物群落的组成和代谢物 (例如,SCFA,内醇) 的形状.
- 纤维微生物群相互作用与肥胖,T2D,NAFLD,IBD,CRC和神经认知障碍有关.
- 目前的研究主要是临床前的,这表明临床翻译存在差距.
结论:
- 理想的食纤维模型为针对微生物群的饮食设计提供了一个框架.
- 将微生物组分层与纤维结构功能数据的整合是精密营养的关键.
- 严格的临床验证是必要的,以确定这个模型的治疗潜力.
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