作为骨老化的生物标志物的表观遗传钟:来自双胞胎研究的证据
Mette Soerensen1,2, Florence Figeac3, Kaare Christensen1,2
1The Danish Twin Registry and the Research Unit for Epidemiology, Biostatistics, and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Aging cell
|September 14, 2025
概括
表观遗传钟是生物年龄的指标,与骨质疏松症和骨折风险有关. 较快的衰老和较短的端粒长度与骨衰老和疾病发病率的增加相关.
科学领域:
- 老年学是一门学科.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 骨生物学 骨生物学 骨生物学
背景情况:
- 骨质疏松症的风险与骨衰老有关.
- 表观遗传机制影响骨衰老,但它们与表观遗传钟的联系尚未得到充分研究.
- 表观遗传钟被认为是生物衰老的生物标志物.
研究的目的:
- 调查八个表观遗传钟和基于甲基化的端粒长度 (mTL) 与骨质疏松症和骨折风险之间的关联.
- 探索表观遗传钟作为骨老化的生物标志物的实用性.
主要方法:
- 利用了来自两个双胞胎队列 (发现和复制) 的数据,追踪时间长达2022.
- 在基线评估了八个表观遗传钟和mTL.
- 在个人和双胞胎对水平上分析了与事件骨折和骨质疏松症诊断的关联,包括骨矿物质密度 (BMD) 和营业额标记 (CTX,P1NP) 在子集中.
主要成果:
- 增加的表观遗传年龄,更快的表观遗传衰老速度和更短的mTL始终与更高的骨折和骨质疏松症风险有关.
- 杜内丁PoAm,杜内丁PACE和GrimAge显示出最强大的关联,而杜内丁PACE显示出最大的效果大小.
- 随着生物年龄的增加,观察到CTX和P1NP水平的降低,表明骨重塑受损. 年龄较大的女性在DunedinPoAm和GrimAge的BMD上表现出类似的趋势.
结论:
- 表观遗传钟和mTL与骨衰老和骨质疏松症风险有关.
- 特定的表观遗传钟,特别是DunedinPACE,GrimAge和DunedinPoAm,显示出作为骨衰老生物标志物的巨大潜力.
- 这些发现强调了生物衰老在骨健康和骨折易受性方面的作用.
关键词:
年龄加速的加速度.骨老化 骨老化 骨老化骨折 骨折 骨折 骨折 骨折 骨折骨矿物质密度 骨矿物质密度骨头翻转标记物标记物标记物遗传表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表骨质疏松症是一种骨质疏松症.他们是双胞胎,双胞胎.更多相关视频
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