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Updated: Jan 17, 2026

Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study
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埃拉芬的表达受到人类支气管上皮细胞中CFTR突变和TGFβ1的调节

Jan Christoph Thomassen1, Christina Vohlen2, Ernst Rietschel3

  • 1CF Center, Children's Hospital, Faculty of Medicine, University of Cologne, Germany; Translational Experimental Pediatrics - Experimental Pulmonology, Children's Hospital, Faculty of Medicine, University of Cologne, Germany.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
|September 14, 2025
PubMed
概括

囊性纤维化 (CF) 肺部疾病涉及炎症和矩阵重塑. 这项研究揭示了CFTR突变降低了elafin表达,而TGFβ1加剧了这种情况,表明了治疗潜力.

关键词:
在CFTR-突变.伊拉芬 伊拉芬 伊拉芬蛋白质酶的恒温状态.人类支气管上皮细胞炎症 炎症是一种炎症.中性动物弹性酶.在TGFβ1中.

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