在猪冠状动脉中,三种药物输送装置之间的药理学比较
Takamasa Tanaka1, Rika Kawakami1, Tatsuya Shiraki1
1CVPath Institute, Inc., Gaithersburg, MD, USA.
概括
在SELUTION SLRTM (SEL-SEB) 证明了持续的药物在动脉中的保留,类似于XIENCETM (EES). 这表明SEL-SEB在没有永久植入物的皮肤冠状动脉干预中提供了持久的结果.
科学领域:
- 心血管医学 心血管医学
- 生物材料科学是生物材料的科学.
- 药理动力学 药理动力学
背景情况:
- 通过皮肤冠状动脉干预 (PCI) 的导管药物输送方面的进展.
- 药物涂层气球 (DCBs) 为动脉样硬化病变提供无植入的分娩.
- 在DCB的药理动力学变化影响临床疗效和安全性.
研究的目的:
- 为了比较SELUTION SLRTM (SEL-SEB) 和MagicTouchTM (MT-SCB) 药物涂层气球与 XIENCETM (EES) 药物排泄支架的药理学特征.
- 在猪模型中评估动脉和心肌药物保留90天.
主要方法:
- 用SEL-SEB,MT-SCB或EES治疗的尤卡坦小型猪 (n=27) 的药理动力学分析.
- 治疗动脉和心肌下游的药物水平测量在7,60和90天.
- 使用SEL-SEB (两步) 和MT-SCB (ZnSO4/甲醇) 的特定提取方法.
主要成果:
- 在60天 (1146.3 ng/g) 和90天 (360.7 ng/g) 后,SEL-SEB呈现持续高的动脉药物水平,与EES (837.3 ng/g和916.5 ng/g) 相似.
- MT-SCB显示动脉药物水平在60天 (5.8 ng/g) 后急剧下降,90天 (2.0 ng/g) 后水平可以忽略不计.
- 7天后心肌药物水平在MT-SCB (281.5 ng/g) 中最高,在SEL-SEB (11.3 ng/g) 中中等,在EES (0.1 ng/g) 中最低.
结论:
- 与MagicTouchTM相比,SELUTION SLRTM显示出优越且持续的动脉药物保留.
- 在SEL-SEB的药物动力学特征上,它非常接近金级标准的XIENCETM支架.
- 这些发现支持SEL-SEB在PCI中具有持久临床结果的潜力,而不需要永久植入物.
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