开发一种新的评分指数,以量化在儿童的干细胞移植和基因治疗期间对营养支持干预措施的需求
Gerard Gurumurthy1, Rebecca Dixon2, Victoria Whiteley2
1The University of Manchester, Manchester, UK.
概括
一个新的营养强度得分量化了对接受干细胞和基因治疗的儿童的饮食支持. 这一分数有助于评估营养干预措施的负担,并有助于规划患者护理和服务.
科学领域:
- 儿科血液学/瘤学
- 营养科学 营养科学
- 移植医学 移植医学 移植医学
背景情况:
- 接受干细胞和基因治疗的儿科患者面临着重大的营养挑战.
- 营养状况影响患者的结果,但没有指数可以量化儿童的饮食干预强度.
- 开发了一种新的营养强度评分来评估移植后的干预类型和持续时间.
研究的目的:
- 为接受干细胞和基因治疗的儿科患者开发和验证营养强度评分.
- 在移植后的前100天内量化营养支持的累积负担.
- 在第100天确定对肠道营养 (PN) 需求的预测因素.
主要方法:
- 对131名移植后或基因治疗后的儿科患者进行了回顾性分析.
- 营养干预分为五个级别,加权分.
- 累计营养强度得分计算为干预点乘以持续时间 (天).
主要成果:
- 营养强度得分根据治疗方式 (CAR-T,全基因,基因疗法) 有显著差异.
- 具有恶性疾病的异构移植接受者和接受全身辐射 (TBI) 的人显示出更高的营养强度得分.
- 更高的营养强度得分,恶性疾病和TBI预测了在第100天需要亲肠道营养 (PN) 的需求.
结论:
- 开发的营养强度得分有效地反映了儿科患者营养干预措施的累积负担.
- 该得分可以为儿科干细胞和基因治疗的患者和服务规划提供信息.
- 需要进一步的前性研究来验证这种营养评分的预测价值.
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