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Updated: Jan 17, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Published on: October 26, 2015

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开发新的策略来构建伪自然的宏观循环,用于无法治疗的目标

Han Wang1,2, Tongyu Bi1,2, Weibo Yang1,2

  • 1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Accounts of chemical research
|September 15, 2025
PubMed
概括

研究人员开发了一种模块化仿生策略,以创建伪自然的宏循环,以准无毒蛋白质. 这种方法使药物发现的多样化宏循环的可持续合成成为可能,解决了治疗复杂疾病的挑战.

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Targets for Drug Action: Overview

Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
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Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
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