自伤行为与严重精神障碍中较早发病的心血管疾病有关
Synve Hoffart Lunding1,2, Isabel Viola Kreis2, Linn Rødevand2
1Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
概括
患有严重精神障碍 (SMD) 的个人,表现出自我伤害行为 (SHB) 或有过自杀企图的历史,面临心血管疾病 (CVD) 的早期发病. 这些因素可能有助于预测该人群中心血管疾病风险.
科学领域:
- 精神病学是一个精神病学.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 严重的精神障碍 (SMD) 与预期寿命显著减少有关,心血管疾病 (CVD) 是主要的贡献者.
- 遗传因素可能是SMD和CVD之间共同脆弱性的基础.
- 了解SMD人群中CVD发病相关的临床特征对于有针对性的干预至关重要.
研究的目的:
- 研究SMD患者的特定临床特征与他们首次CVD诊断的时间之间的关联.
- 在SMD群体中识别潜在的心血管疾病风险早期指标.
主要方法:
- 分析了1627名患有精神分裂症谱系 (SCZ) 或双极谱系障碍 (BDs) 的参与者和1201名健康对照者的队列.
- 心血管疾病的诊断是从挪威国家卫生登记处 (2006-2020年) 提取的.
- 考克斯的比例危险模型被用来评估SMD临床特征与首次心血管疾病诊断的时间之间的关系,控制共变量.
主要成果:
- 患有SMD的个体的反复自我伤害行为 (SHB) 与早期首次心血管疾病诊断有显著的关联 (p=.029).
- 在那些有SHB和自杀未遂史的人中,更多的自杀未遂与较早的心血管疾病发作相关 (p=.041).
- 在初次心血管疾病诊断的时间和SMD发病时的年龄或并发性物质使用障碍之间没有发现显著的关联.
结论:
- 在SMD患者中,自我伤害行为 (SHB) 和自杀企图史与早发性心血管疾病 (CVD) 有关.
- 这些临床因素可能会提高心血管疾病的预测准确度,超出SMD人口中的传统风险因素.
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