周围甲状腺激素敏感度调解了在成人甲状腺上腺体的身体组成和糖尿病之间的关联
Nanfang Yao1,2, Lan Liu1,3, Yuqi Jiang1
1Department of Endocrinology and Metabolism, The Eighth Affiliated Hospital of Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China.
较高的脂肪与肌肉比率 (FMR) 和较低的尾骨肌肉质量/体重指数 (ASM/BMI) 与非甲状腺成年人糖尿病风险增加有关. 周围甲状腺激素敏感性 (FT3/FT4比率) 部分介导ASM/BMI对糖尿病的保护作用.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 身体组成分析 身体成分分析
背景情况:
- 像脂肪与肌肉比率 (FMR) 和尾骨肌肉质量 (ASM) 这样的身体组成参数与代谢疾病有关.
- 在这些关联中,外围甲状腺激素敏感性 (自由三甲状腺素与自由甲状腺素的比率,FT3/FT4比率) 的作用在无甲状腺症患者中尚不清楚.
研究的目的:
- 为了调查FMR和ASM/BMI与糖尿病之间的关联,在中国成年 euthyroid.
- 探索FT3/FT4比率在这些关系中的潜在调解作用.
主要方法:
- 在中国广东省5089名甲状腺功能良好的成年人的横截面研究.
- 通过生物电阻分析 (BIA) 测量身体成分.
- 糖尿病通过空腹血葡萄糖,2小时后负载葡萄糖或HbA1c进行评估;使用多变量逻辑回归和结构方程建模分析的关联.
主要成果:
- 较高的FMR (第三位) 与79%的糖尿病患病率增加有关 (OR 1.79).
- 较高的ASM/BMI (第三位) 与56%降低的糖尿病患病率 (OR 0.44) 有关.
- 在ASM/BMI和糖尿病之间的关联中,FT3/FT4比率显著介导了4.6%.
结论:
- 升高的FMR和降低的ASM/BMI独立地与平甲状腺患者糖尿病患病率的增加有关.
- FT3/FT4比率可能部分调解ASM/BMI和糖尿病之间的逆关系,表明在血糖调节中发挥作用.
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