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针对癌症干细胞的抗体-药物结合剂用于癌症免疫疗法

Gyas Khan¹, Ali Hanbashi¹, Wedad Mawkili¹

¹Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan, 45142, Saudi Arabia.

Current medicinal chemistry

|September 15, 2025

概括

抗体-药物联合体 (ADCs) 提供了一种有希望的策略来向癌症干细胞 (CSCs),这些干细胞驱动瘤生长和耐药性. ADCs专门向CSC传递细胞毒性有效载荷,在各种癌症中表现出潜力.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
药物开发药物开发

背景情况:

癌症干细胞 (CSCs) 在癌症发病,转移和治疗耐药性方面至关重要.
抗体-药物合物 (ADC) 正在成为消除CSC和预防复发的向疗法.

研究的目的:

审查针对 CSC 的 ADC 的机制,最近的进展和未来前景.
突出CSC向ADCs在彻底改变精确瘤学和癌症免疫疗法的潜力.

主要方法:

ADCs使用单克隆抗体对抗与细胞毒性有效载荷结合的CSC表面标记物 (例如CD44,CD133).
在抗原结合后的内部化触发了有效载荷释放和CSC亡.
临床前研究评估了针对各种癌症的CD133和CD44的ADC;针对EpCAM的ADC在上皮瘤中显示出有效性.

主要成果:

针对CSC的ADC,包括针对CD133,CD44和EpCAM的ADC,在临床前癌症模型中显示出有效性.
最近的ADC技术进步提高了选择性,降低了毒性.
新兴的策略,如双特异性抗体和优化的链接剂,可以增强ADC的潜力.

结论:

针对CSC的ADCs代表了精确瘤学的重大进步,提供了一种克服癌症干性和治疗耐药性的策略.
挑战包括CSC异质性和生物标志物特异性,需要在ADC工程和组合疗法方面进一步创新.
持续的研究和临床评估对于实现CSC向性ADC在癌症治疗中的全部潜力至关重要.

关键词:

癌症干细胞是癌症干细胞.抗体 - 药物联合体药物耐药性耐药性药物耐药性免疫疗法免疫疗法精密瘤学. 精密瘤学.有针对性的治疗.瘤微环境是一个微环境.

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