包括对基于数据的虚拟双胞胎进行有氧运动,用于血糖模拟
Oriol Bustos1,2, Omer Mujahid1,2, Iván Contreras1,2
1Modelling and Intelligent Control Engineering Laboratory, Institut d'Informatica i Aplicacions, Universitat de Girona, Girona, Spain.
Journal of diabetes science and technology
|September 15, 2025
概括
这项研究通过将有氧运动数据集成到生成对抗网络中来增强糖尿病的虚拟患者模型,改进了个性化疗法和自动化胰岛素输送系统的模拟.
科学领域:
- 生物医学工程 生物医学工程
- 计算生物学 计算生物学
- 内分泌学 在内分泌学.
背景情况:
- 数据驱动模型对于糖尿病管理中的虚拟患者模拟至关重要.
- 个性化疗法需要精确的,与机器学习兼容的个性化模型.
- 像GAN这样的深度生成模型为先进的生理模拟提供了潜力.
研究的目的:
- 开发一种扩展的条件瓦斯斯坦生成对抗网络 (GAN) 模型,用于糖尿病代谢.
- 将有氧运动强度数据与胰岛素和碳水化合物数据相结合.
- 提高虚拟患者模型在糖尿病研究中的准确性和适用性.
主要方法:
- 开发了一个扩展的条件瓦瑟斯坦GAN,整合了有氧运动强度,胰岛素和碳水化合物数据.
- 采用有氧体力活动模型来模拟运动对血糖的直接和长时间影响.
- 该模型经过训练和验证,使用56名患者的1479天数据,包括308次炼.
主要成果:
- 该模型准确地复制了T1DEXI研究中的真实数据,包括平均血糖和时间在/上/下范围的指标.
- 对总和数据和分离的活跃日与静止日的表现进行了验证.
- 该模型成功地重现了运动诱导的葡萄糖降低.
结论:
- 改进后的模型为包含体力活动的in silico试验提供了更可靠的框架.
- 这一进步对设计和验证自动化胰岛素输送系统具有重大潜力.
- 该模型改善了糖尿病研究和治疗开发的虚拟患者代表性.
相关概念视频
01:20Exercise and Cardiovascular Response
3.9K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
3.9K
01:13Outcomes of Glycolysis
106.7K
Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
106.7K
01:22Diabetes Mellitus: Type 2 and Gestational
4.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
01:15Model Approaches for Pharmacokinetic Data: Physiological Models
249
Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
249
01:24Other Glycolytic Pathways
831
The pentose phosphate pathway (PPP) operates in parallel with glycolysis, facilitating the metabolism of both pentoses and glucose. This pathway consists of two distinct phases: the oxidative and non-oxidative phases. While it does not directly generate ATP, the intermediates formed during the process can integrate into glycolysis, contributing to cellular energy metabolism when required.Oxidative Phase: NADPH ProductionThe oxidative phase of the pentose phosphate pathway is primarily...
831
01:25Metabolic Rate
1.1K
The human body is a powerhouse of energy, with every cell performing numerous functions that require energy. This energy production and consumption is measured by the metabolic rate, which quantifies the total heat generated by all the body's chemical reactions and mechanical work. This measurement helps to determine the rate of kilocalorie (kcal) consumption needed to fuel all ongoing activities.
The Basal Metabolic Rate (BMR) measures the energy expended at rest.
Several factors influence...
The Basal Metabolic Rate (BMR) measures the energy expended at rest.
Several factors influence...
1.1K