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通过光诱导的Pd和Pd/Ir继电器催化作用组装Tsuji-Trost反应

Bo-Yuan Xie¹, Zhi-Tao He^1,2,3

¹State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Shanghai, 200032, China.

Angewandte Chemie (International ed. in English)

|September 15, 2025

概括

这项研究引入了一种创新的激发催化TSUJI-TROST反应,使用易于获得的起始材料. 这种新方法能够高效地合成各种基化合物,具有出色的立体控制,包括所有四种立体同位素.

科学领域:

有机化学有机化学
催化剂是一种催化剂.
合成方法论合成方法论

背景情况:

传统上,Tsuji-Trost反应需要具有阿尔法脱离组的特定基.
从这种反应的基本化学物质开发现场组装方法是一个尚未探索的领域.

研究的目的:

报道了一种新兴的催化在现场组装的Tsuji-Trost反应.
从简单的原料化学品中合成各种基化合物.

主要方法:

为 (E) - 基化合物开发HAT/Heck/化级联协议.
对 (Z) - 化合物进行光诱导的/继电触媒的设计.
使用易于获得的基因,基因和核基因作为基质.

主要成果:

对各种 (E) - 基化合物实现了良好的产量和立体选择性.
启用了具有挑战性的 (Z) - 基化合物的立体选择性合成.
证明了所有四种可能的立体同位素的立体分离合成 [(E,R), (E,S), (Z,R), (Z,S) ].
展示了与N-,C-,O-和S衍生的核友,和的广泛基质兼容性.

结论:

开发的兴奋状态化学提供了一种强大而通用的方法来合成基化合物.
该协议适用于生物活性分子的简洁合成,证明了其实用性.
机理学研究验证了拟议的反应途径.

关键词:

在现场组装结合酶的结合酶.在Pd/Ir中继催化.光诱导的Pd催化作用立体变异的立体变异.Z/E 可控制的

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