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先天性甲状腺功能低下症:长期增长和智力结果与较低的初始levothyroxine剂量

Jun-Hong Park¹, Jae Hyuk Oh¹, Min Hyung Cho¹

¹Department of Paediatrics, Ajou University School of Medicine, Suwon-si, Gyeonggi-do, Republic of Korea.

Clinical endocrinology

|September 15, 2025

概括

这项研究发现,在患有先天性甲状腺功能低下症 (CH) 的儿童中,初始的Levothyroxine剂量没有显著影响长期的生长或神经发育结果. 在不同初始剂量组中观察到有利的结果,表明治疗灵活性.

科学领域:

儿科内分泌学儿科内分泌学
发育儿科发育儿科
代谢障碍代谢障碍代谢障碍

背景情况:

遗传性甲状腺功能低下症 (CH) 需要终身的Levothyroxine替代疗法.
优化Levothyroxine的初始剂量对于CH患者的长期结果至关重要.
了解初始剂量对生长和神经发育的影响对于临床实践至关重要.

研究的目的:

评估儿童先天性甲状腺功能低下症 (CH) 的长期结果.
要确定与患者或治疗相关的因素,特别是Levothyroxine初始剂量是否影响这些结果.
评估初始低剂量和高剂量的levothyroxine对生长和神经发育的影响.

主要方法:

在2003年至2024年期间对144名CH儿童进行了回顾性,横截面研究.
低 (<10毫克克朗/公斤) 和高 (≥10毫克克朗/公斤) 初始Levothyroxine剂量组之间的比较分析.
进行了纵向生长评估和智商 (IQ) 多变量回归分析.

主要成果:

大多数儿童表现出正常的生长和认知功能,无论初始的Levothyroxine剂量.
低剂量组和高剂量组之间没有观察到生长参数 (骨龄-年代年龄,身高,体重,BMI z-分数) 的显著差异.
初始剂量组没有显著影响全尺度智商得分.

结论:

患有CH的儿童表现出有利的长期线性生长和神经发育结果.
较低的Levothyroxine初始剂量在实现积极的长期结果方面似乎与较高剂量一样有效.
这些发现支持了在CH治疗中个性化初始Levothyroxine剂量策略的潜力.

关键词:

利沃甲氧氨酸/治疗用途骨发育骨的发育骨的发展出生性甲状腺功能低下症.增长的增长增长的增长增长的增长.情报测试情报测试情报测试情报测试纵向研究是指纵向研究.新生儿查新生儿查

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