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间歇性禁食诱导的自性正常化在与代谢功能障碍相关的脂肪肝疾病中提供肝脏保护:机制性见解和影响
Payal Bhatnagar1, Gehan El-Akabawy2,3,4, MoezAlIslam E Faris5
1Department of Pharmaceutical Technology, School of Pharmacy, IMU University, Kuala Lumpur, Malaysia.
Histology and histopathology
|September 15, 2025
概括
间歇性禁食 (IF),就像斋月间歇性禁食 (RIF),可以通过恢复自来改善与代谢功能障碍相关的脂肪肝疾病 (MAFLD). 这个过程有助于清除细胞损伤和多余的脂质,减少肝脏脂肪,防止疾病的进展.
科学领域:
- 代谢和肝脏疾病研究研究
- 细胞生物学和自机制.
- 营养和生活方式干预措施
背景情况:
- 代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是一种与自功能障碍相关的渐进性肝病.
- 自是一种细胞降解过程,对于清除损坏的成分和多余的脂质至关重要.
- 损坏的自会对MAFLD的发病有显著的贡献,这突显了需要治疗策略来恢复其功能.
研究的目的:
- 审查自的机制及其在MAFLD中的功能障碍.
- 探索间歇性禁食 (IF) 的潜力,特别是斋月间歇性禁食 (RIF),作为MAFLD的治疗策略.
- 总结关于IF和RIF如何能使自正常化,减少肝硬化和改善肝功能的证据.
主要方法:
- 文献综述总结了各种形式的IF.
- 对自机制及其在MAFLD中的作用研究的分析.
- 对人类和动物研究的审查,调查IF和RIF对肝脏健康和自标志物的影响.
主要成果:
- 自功能障碍与MAFLD的发展和进展有关.
- 包括RIF在内的IF在人体组成,葡萄糖调节和肝功能方面已经证明有好处.
- 已经证明,RIF可以降低体重,BMI,脂肪质量和炎症标志物,同时改善肥胖和MAFLD患者的肝硬化和肝功能.
- RIF增强了与自相关的基因的表达,并恢复了自流动.
结论:
- 恢复自是一种对MAFLD的潜在治疗途径.
- 间歇性禁食,特别是RIF,在正常化自和改善肝脏肥胖症方面表现有前途.
- RIF对自的积极影响表明,它可以成为管理MAFLD的有价值的非药物干预措施.
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