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Updated: Jan 17, 2026

Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy
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准心肌细胞PCNA和POLD1可以预防心肌病性心肌缩

Soumojit Pal1, Michael S Glennon1, Benjamin R Nixon1

  • 1Division of Cardiology, Department of Medicine and Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, PA (S.P., M.S.G., B.R.N., E.J.C., P.S., C.M.K., M.B.G., C.J.W., L.G., N.G.C., D.B., J.H.K., J.R.B.).

Circulation research
|September 15, 2025
PubMed
概括

准DNA合成途径,特别是PCNA-POLD1,可以减少病态心肌细胞生长和缩. 蛋白质p21作为负调节剂,为心脏病提供治疗潜力.

关键词:
心肌病,高性心肌病,高性心肌病.疾病模型,动物模型.经批准的重复复制.心脏衰竭是因为心脏衰竭.过度缩的过度缩是一个问题.肌细胞,心脏细胞.多重积分多样性 多重积分多样性

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