相关实验视频

Updated: Jan 17, 2026

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

在严重阻塞性睡眠呼吸暂停患者中,循环miRNA-205和系统性炎症状态之间的相关性分析

Tuerxun Subijiang^1,2,3,4,5, Xiao-Guang Yao^1,2,3,4,5, Ting Wu^1,2,3,4,5

¹Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China.

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

|September 15, 2025

概括

患有严重阻塞性睡眠呼吸暂停 (OSA) 的患者的循环miRNA-205水平较低,系统性炎症指数 (SII和SIRI) 较高. 较低的miRNA-205表达可能会缓解严重OSA的炎症状态.

科学领域:

生物医学科学生物医学科学
分子生物学分子生物学
睡眠医学睡眠医学

背景情况:

阻塞性睡眠呼吸暂停 (OSA) 与全身炎症有关.
微RNAs (miRNAs) 在炎症过程中发挥作用.
循环miRNA-205和系统性炎症指数,如SII和SIRI,在OSA中进行调查.

研究的目的:

在严重的OSA患者中,探索循环miRNA-205表达和全身炎症标志物 (SII和SIRI) 之间的关系.
评估miRNA-205,SII,SIRI和OSA严重程度参数之间的相关性.

主要方法:

使用定量逆转录PCR测量miRNA-205的表达.
进行了常规血液测试,以计算SII和SIRI.
使用简单的回归分析来确定患有和没有严重OSA的患者之间的相关性.

主要成果:

与非OSA患者相比,严重OSA患者的miRNA-205表达显著降低,SII和SIRI的SII和SIRI较高.
在严重的OSA中,呼吸暂停-呼吸暂停指数 (AHI) 与miRNA-205负相关,与SII和SIRI正相关.
增加的miRNA-205与降低的SII有关,这表明潜在的缓解作用.

结论:

严重的OSA的特征是下调的miRNA-205和升高的全身炎症标志物 (SII和SIRI).
低miRNA-205表达可能对严重的OSA系统性炎症状态产生负面缓解作用.

关键词:

炎症指数炎症指数这是一个小RNARNA.阻塞性睡眠呼吸暂停 (SOP) 的情况.

更多相关视频

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

Published on: October 26, 2017

Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice

Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice

Published on: January 7, 2019

相关概念视频

Sleep Apnea

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...