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对于BCG不响应的非肌肉侵入性膀癌的全身免疫疗法

Karima Oualla¹, Mehdi Alem¹, Jeremy Teoh²

¹Medical Oncology Department, Hassan II University Hospital, Sidi Mohamed Ben Abdellah University, Fes, Morocco.

Current opinion in urology

|September 15, 2025

概括

系统性免疫疗法为Bacillus Calmette-Guérin (BCG) 耐药的非肌肉侵入性膀癌 (NMIBC) 提供了新的膀节省选择. 像免疫检查点抑制剂这样的进步正在改变这种具有挑战性的疾病患者的治疗方法.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
在瘤学瘤学.
免疫治疗是一种免疫疗法.

背景情况:

非肌肉侵入性膀癌 (NMIBC) 耐受于Bacillus Calmette-Guérin (BCG) 治疗是一个重大的临床挑战.
对于BCG耐药NMIBC的患者,存在有限的膀节约治疗策略.

研究的目的:

审查BCG耐药NMIBC系统免疫疗法的最新进展.
为突出这种疾病患者不断变化的治疗范式.

主要方法:

对BCG耐药NMIBC系统免疫疗法的当前文献的综述.
分析新兴的治疗策略和分子标.

主要成果:

免疫检查点抑制剂 (如 pembrolizumab) 和基因疗法表现出治疗上的成功,并获得了对高风险BCG耐药NMIBC的监管批准.
包括免疫疗法与静脉内疗法或化疗在内的组合疗法正在研究中,以提高疗效和克服耐药性.
新型分子标的识别和个性化策略的开发正在迅速推进这一领域.

结论:

系统性免疫疗法为BCG耐药NMIBC的患者提供了一个有前途的膀节省治疗选择.
这些发现支持向个性化和不那么侵入性治疗方法的转变.
需要进一步的研究来优化结果,扩大治疗选择,并提高患者的生活质量.

关键词:

没有对BCG反应的BCG不响应.免疫检查点抑制剂免疫检查点抑制剂膀癌是非肌肉侵入性的膀癌.

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