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异常的细胞质p53染色在口腔状细胞癌和发育不良:临床病理学和分子研究

Lingxin Zhang^1,2, Tony Ng³, Lien Hoang³

¹Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada.

The American journal of surgical pathology

|September 15, 2025

概括

在口腔癌中异常的p53细胞质染色与影响核定位的TP53突变有关. 这一发现有助于诊断口腔平状细胞癌和口腔上皮质发育不良.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
病理学病理学病理学

背景情况:

细胞质上对p53的分离是致癌的一个已知的机制.
异常的p53细胞质染色通过免疫组织化学 (IHC) 在口腔状细胞癌 (OSCC) 和口腔上皮质发育不良 (OED) 中报告不足.

研究的目的:

为了研究OSCC和OED与异常的p53细胞质染色的临床病理特征.
使用下一代测序 (NGS) 将这种染色模式与TP53突变相关联.

主要方法:

分析了4个OSCC和10个OED的p53细胞质染色.
下一代测序 (NGS) 用于识别TP53突变.
评估影响核定位序列 (NLS) 和核排除序列 (NES) 的突变.

主要成果:

细胞质p53染色模式与破坏NLS或NES的TP53突变相关.
在TCGA队列中的TP53-突变头支状细胞癌 (HNSCC) 样本中,在8.7%至11.0%的样本中发现了高影响的NLS改变突变.
这项研究为HNSCC和OED中异常的p53细胞质染色提供了实际定义.

结论:

异常的p53细胞质染色是一种诊断陷,在HNSCC和OED中具有潜在的生物学影响.
建议更新一个p53 IHC解释算法,以帮助进一步的研究和数据收集.

关键词:

TP53核定位序列的核定位序列.细胞质p53模式的图案头部和部状细胞癌瘤口腔上皮质发育不良症

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