播种和养:营养和与出生相关的暴露影响了母乳养婴儿的肠道微生物组组
Lisa F Stinson1,2,3, Isabella Norrish4, Faith Mhembere5
1School of Molecular Sciences, The University of Western Australia, Perth, Australia.
Gut microbes
|September 15, 2025
概括
哺乳支持婴儿肠道微生物组的稳定,缓冲早期的干扰. 固体食品的引入显著改变了微生物的多样性和组成,而断奶的影响最小.
科学领域:
- 微生物组研究的研究.
- 儿科卫生健康 儿科卫生健康
- 人类牛奶中的寡糖类.
背景情况:
- 早期的肠道微生物组建立对于长期健康至关重要.
- 婴儿饮食显著影响微生物组成,但母乳养婴儿的数据有限.
- 出生干预可以影响婴儿肠道微生物群的发展.
研究的目的:
- 为了研究肠道微生物组的纵向发育,专门或主要母乳养的婴儿.
- 评估饮食过渡 (固体食品的引入,断奶) 和分娩干预 (剖腹产) 对婴儿肠道微生物群的影响.
- 了解母乳养在中介早期微生物组扰乱中的作用.
主要方法:
- 从84名婴儿 (1周到2岁) 的698个便样本的纵向分析,使用全长16S rRNA基因测序和qPCR.
- 分析微生物组的组成,多样性和特定细菌的丰度随着时间的推移.
- 基于养状态和输送方式的微生物特征的比较.
主要成果:
- 婴儿肠道微生物组在2-5个月之间稳定,在引入固体食物后,多样性和重组显著增加.
- 断奶对整体微生物群的影响很小,但减少了Bifidobacterium物种,表明母乳具有持续的双生效.
- 剖腹产显示了Bacteroides的短暂减少,但Bifidobacterium没有,这表明母乳养的保护作用.
结论:
- 哺乳可能缓冲生命早期的微生物群干扰,促进稳定性.
- 饮食过渡,特别是固体食品的引入,对婴儿肠道微生物群产生重大和持久的影响.
- 绝对丰度测量对于准确评估微生物变化至关重要,特别是在应对干预时.
相关概念视频
Anatomy of the Intestines
86.8K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
86.8K
Microbial Nutrition
1.1K
Organisms exhibit remarkable metabolic diversity, categorized based on how they acquire energy and carbon. These strategies enable survival in various ecological niches and are essential for maintaining energy flow and nutrient cycling within ecosystems.Energy and Carbon SourcesOrganisms are classified as phototrophs or chemotrophs based on energy acquisition. Phototrophs use light as their energy source, while chemotrophs rely on oxidizing chemical compounds. Further differentiation arises...
1.1K
Bulimia Nervosa
692
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
692
Bacterial Flora of the Large Intestine
1.5K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.5K


