肺栓塞的危险因素在恶性瘤患者下肢深静脉血栓症:一个回顾性研究
Junfeng Li1, Zhen Li2, Hui Zheng3
1Department of Vascular Surgery, The Second Affiliated Hospital of Shandong First Medical University Tai'an, Shandong, China.
American journal of cancer research
|September 15, 2025
概括
在患有下肢深静脉血栓症 (LLDVT) 的癌症患者中,肺栓塞 (PE) 风险因素包括LLDVT密度比,同素 (Hcy) 和心脏素I (cTNI). 这些标志物有助于在这个高风险群体中管理PE.
科学领域:
- 在瘤学瘤学.
- 血管医学 血管医学
- 诊断成像 诊断成像 诊断成像
背景情况:
- 恶性瘤显著增加了静脉血栓栓塞的风险,特别是深静脉血栓塞 (DVT) 和肺栓塞 (PE).
- 在患有下肢深静脉血栓症 (LLDVT) 的癌症患者中确定PE的特定风险因素对于及时干预和改善结果至关重要.
研究的目的:
- 在被诊断患有恶性瘤和下肢深静脉血栓症 (LLDVT) 的患者中确定肺栓塞 (PE) 的独立风险因素.
- 为了评估LLDVT密度比的预测值,D-二次体,同型氨酸 (Hcy) 和心脏素I (cTNI) 在这个患者队列中对PE进行预测.
主要方法:
- 从45名PE患者 (观察组) 和255名非PE患者 (对照组) 获得的临床数据的回顾性分析.
- 组间临床参数比较,包括LLDVT密度比,D-二次数,Hcy,cTNI和Wells分数.
- 后勤回归和皮尔森相关性分析以确定独立的风险因素及其与PE的关联.
主要成果:
- 与对照组相比,PE患者的LLDVT密度比率,D-二次体,Hcy,cTNI和Wells分数显著更高.
- 确定了LLDVT密度比率,Hcy,cTNI和Wells分数作为PE的独立风险因素.
- 使用LLDVT密度比率,Hcy和cTNI的组合模型显示,PE预测的曲线下的高面积 (AUC) 为0.852.
结论:
- 在患有LLDVT的恶性瘤患者中,LLDVT密度比,Hcy和cTNI是PE的显著独立预测因素.
- 这些标志物与PE严重程度有很强的相关性,为临床管理提供了宝贵的见解.
- 通过利用这些预测标志物,可以增强针对这种高风险人群的优化临床策略.
相关概念视频
Pulmonary Embolism III: Nursing Management
364
A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
364
Pulmonary Embolism I: Introduction
521
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
521
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
329
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
329
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
294
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
294
Venous Thrombosis I: Introduction
375
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
375
Venous Thrombosis III: Interprofessional Care
280
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
280


