thalidomide与ifosfamide相结合显著改善了肺转移性骨髓瘤患者的存活率
Yuanxiang Liu1, Huabin Wang1, Zhengkai Xiang1
1Department of Thoracic Surgery/Bone and Soft Tissue Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430079, Hubei, China.
American journal of cancer research
|September 15, 2025
概括
thalidomide与ifosfamide (IFO) 结合,可显著改善肺转移性骨肉瘤患者的无进展生存期 (PFS) 和整体生存期 (OS). 这种疗法还显示出与ifosfamide加etoposide (ETOP) 相比更高的安全性.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 医学研究 医学研究
背景情况:
- 骨髓瘤是一种主要的骨恶性瘤,对肺转移的倾向很高.
- 目前肺转移性骨肉瘤的治疗方案需要优化,以提高疗效和降低毒性.
研究的目的:
- 为了评估thalidomide与ifosfamide (IFO) 结合用于肺转移性骨髓瘤的疗效和安全性.
- 为了比较thalidomide + IFO疗法与标准的ifosfamide + etoposide (ETOP) 疗法.
主要方法:
- 对95名病理确诊骨髓瘤患者的回顾性分析.
- 观察组 (thalidomide + IFO,n=55) 和对照组 (IFO + ETOP,n=40) 的比较.
- 评估无进展生存 (PFS),总生存 (OS),客观反应率 (ORR),疾病控制率 (DCR) 和不良反应 (AR).
主要成果:
- 泰利多米德+IFO组的瘤直径显著减少,肺转移性病变明显减少.
- 在thalidomide + IFO组中,中位数的PFS (10个vs7.5个月) 和OS (22个vs14个月) 显著改善.
- 观察到较高的ORR (23.63%与对照组相比) 和DCR (52.73%与对照组相比),血液学,胃肠道和脏毒性的发生率明显较低.
结论:
- thalidomide和ifosfamide (IFO) 的组合是肺转移性骨肉瘤的有效治疗方法.
- 与IFO-ETOP方案相比,该方案提供了改进的PFS和OS,具有更好的安全概况.
- 肺转移性骨肉瘤的独立预后因素包括肺转移的数量,T阶段,N阶段,放射治疗和LDH水平.
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