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Updated: Jan 17, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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克拉里斯罗米辛,伊克萨佐米布,波马利多米德,德克萨米他治疗复发性/耐火性骨髓瘤:生存率和相关性分析

Aaron S Rosenberg1, Emanual Maverakis2, Caitlin Costello3

  • 1Division of Malignant Hematology/Cellular Therapy and Transplantation, University of California Davis School of Medicine, Sacramento, CA.

Blood neoplasia
|September 15, 2025
PubMed
概括

结合克拉里思罗米辛,伊克萨佐米布,波马利多米德和德克萨米松的ClIPd疗法在治疗复发性/耐药性多发性骨髓瘤 (MM) 中显示出有希望的疗效. 这种口服治疗在多发性骨髓瘤患者中实现了高响应率和延长了无进展的生存期.

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