相关实验视频
Updated: Jan 17, 2026

05:05
A Modified Precipitation Method to Isolate Urinary Exosomes
Published on: January 16, 2015
18.0K
主要高血压的新兴外体生物标志物:系统性审查
Dongling Zhong1, Yuan Chen1, Yue Zhang1
1School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Cardiovascular diagnosis and therapy
|September 15, 2025
概括
血液和尿液中的外体生物标志物显示出对诊断和监测高血压及其并发症的前景. 这些微小的囊泡可能有助于识别血管功能障碍,损伤和认知问题.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 异构体被研究为基本高血压 (EH) 进展和并发症的潜在生物标志物.
- 在高血压中对外体生物标志物的现有研究显示出不一致性.
- 本系统性审查综合了与EH相关的外体生物标志物的证据.
研究的目的:
- 在基本高血压中对外体生物标志物进行全面的系统审查.
- 综合证据,以诊断和预后潜力外体生物标志物在EH.
- 确定特定的外体微RNA (miRNA) 和与高血压及其并发症相关的蛋白质.
主要方法:
- 在多个数据库 (PubMed,Embase,Web of Science等) 中进行系统搜索. 对于英语和中文记录.
- 包括所有研究设计,重点是外体微RNA (miRNA) 变化和其他货物类型.
- 使用乔安娜·布里格斯研究所 (JBI) 和ROBINS-I工具进行质量评估,然后进行定性叙事合成.
主要成果:
- 包括11项方法质量中等至高的研究.
- 血液和尿液中的外体生物标志物显示出高血压及其并发症的诊断潜力.
- 特定的外体miRNAs (例如,miR-320d/423-5p,miR-26a-5p,miR-330-3p) 与血管功能障碍,损伤和认知障碍有关.
结论:
- 血液和尿液的异位体生物标志物对于早期诊断,精确的排版和监测高血压相关的位器官损伤是有价值的.
- 未来的研究需要标准化的协议,更大的样本大小,以及对外体生物标志物研究的改进报告.
- 外体生物标志物可能为个性化高血压管理提供分子基础.
相关概念视频
Hypertension III: Clinical Manifestations and Diagnostic Studies
471
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
471
Hypertension and Regulation of Blood Pressure
3.8K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.8K
Hypertension II: Pathophysiology
803
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
803
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
541
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
541
Hypertension I: Introduction
745
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
745
Hormonal Regulation of Blood Pressure
5.9K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
5.9K

