通过巨细胞操纵,增强自然杀手细胞的抗瘤活性
Natasha Palmer1, Salim Khakoo1, Tilman Sanchez-Elsner1
1School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Frontiers in immunology
|September 15, 2025
概括
在瘤微环境 (TME) 中利用巨细胞和自然杀手 (NK) 细胞相互作用,提供了新的癌症治疗策略. 调节这些免疫细胞可以增强抗瘤免疫力,克服治疗阻力.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
背景情况:
- 瘤微环境 (TME) 对癌症的进展,免疫逃避和治疗耐药性至关重要.
- 巨细胞和自然杀手 (NK) 细胞是TME中的关键免疫参与者,它们的相互作用显著影响抗瘤反应.
- 巨细胞的可塑性和NK细胞的效应器功能为癌症免疫治疗带来了挑战和机遇.
研究的目的:
- 审查目前在癌症治疗中操纵巨细胞的策略.
- 探索增强巨细胞和NK细胞之间的交叉声的方法,以提高抗瘤免疫力.
- 突出了解TME中巨细胞-NK细胞动态的先进技术.
主要方法:
- 对基于巨细胞的癌症疗法现有文献的审查.
- 针对巨细胞表型,枯竭和与NK细胞交叉交流的策略分析.
- 讨论新兴技术,如单细胞RNA测序,空间转录组学和蛋白质组学.
主要成果:
- 巨细胞操纵,包括表型再极化和选择性枯竭,可以影响抗瘤免疫力.
- 调节巨细胞和NK细胞之间的交叉声可以增强NK细胞介导的瘤监测.
- 先进的奥米克技术提供了强大的工具来剖析复杂的巨细胞-NK细胞相互作用.
结论:
- 向巨细胞-NK细胞相互作用是新型癌症免疫疗法的一个有希望的途径.
- 了解TME内部的动态相互作用对于开发有效的治疗干预措施至关重要.
- 新兴技术将加速下一代免疫治疗策略的发现.
相关概念视频
Immune Surveillance by NK Cells and Phagocytes
7.9K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
7.9K
Cells of the Innate Immune Response
8.7K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
8.7K
Cytotoxic T Cells-mediated Immune Response
6.5K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
6.5K
Tumor Immunotherapy
1.8K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.8K


