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瘤微环境中的微生物群-巨细胞交叉:对口腔状细胞癌的进展和治疗的影响

Xin Deng¹, Shaohong Huang¹

¹Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.

Frontiers in immunology

|September 15, 2025

概括

口腔细菌失衡通过重编程免疫细胞来促进口腔癌. 调节口腔微生物组或免疫细胞可能会恢复抗瘤免疫力,从而更好地治疗口腔状细胞癌.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
微生物学微生物学

背景情况:

口腔状细胞癌 (OSCC) 的结果不佳,瘤微环境 (TME) 和天生的免疫力,特别是瘤相关的巨细胞 (TAMs),发挥了关键作用.
巨细胞对于免疫反应至关重要,并且可以根据局部线索分化为不同的表型.

研究的目的:

审查OSCC中口腔微生物群失生症和先天性免疫巨细胞之间的复杂相互作用.
要突出涉及免疫抑制,转移和OSCC治疗耐药性的途径.

主要方法:

文献综述总结了OSCC中微生物群-巨细胞相互作用的当前知识.
专注于参与巨细胞极化和TME调制的受体介导信号通路.

主要成果:

口腔失生症是由像*Fusobacterium nucleatum*和*Porphyromonas gingivalis*这样的细菌驱动的,会引发慢性炎症.
致病性细菌通过TLR和CSF-1R促进M2类TAM极化,导致免疫抑制,血管生成和PD-L1表达.
类似M2的TAMs分泌IL-10和TGF-β,促进瘤生长和免疫逃避.

结论:

针对口腔微生物群或重新编程先天性免疫巨细胞为OSCC提供了一个有前途的战略.
通过调节这些相互作用,可以恢复抗瘤免疫力并提高OSCC的治疗疗效.

关键词:

化学因子受体化学因子受体免疫抑制免疫抑制这是一种炎症炎症炎症炎症.我们的微生物群.口腔状细胞癌的癌症.与瘤相关的巨细胞.

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