2型糖尿病对高级非小细胞肺癌全身治疗的影响
Yasuhiro Kato1, Eri Kuramochi1, Rei Yamaguchi1
1Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School Chiba-Hokusoh Hospital, Chiba, Japan.
Translational lung cancer research
|September 15, 2025
概括
2型糖尿病 (T2DM) 对晚期非小细胞肺癌 (NSCLC) 治疗结果产生负面影响,特别是免疫检查点抑制剂. 专家咨询可以改善接受ICI治疗的T2DM患者的无进展生存率.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 临床研究 临床研究
背景情况:
- 2型糖尿病 (T2DM) 对高级非小细胞肺癌 (NSCLC) 治疗的影响尚不清楚.
- 这项研究调查了T2DM如何影响晚期NSCLC患者的治疗疗效和安全性.
研究的目的:
- 评估T2DM对接受全身治疗的晚期NSCLC患者结果的影响.
- 在接受免疫检查点抑制剂 (ICI) 治疗的T2DM患者中确定无进展生存的预后因素.
主要方法:
- 对从2018年到2024年治疗的晚期NSCLC患者的回顾性分析.
- 在T2DM和非T2DM患者队列中比较治疗效应和不良事件.
- 在不同治疗方式 (ICI,MTT,CTT) 中评估整体生存 (OS) 和无进展生存 (PFS).
主要成果:
- 与非T2DM患者相比,T2DM患者的整体生存状况明显恶化,特别是ICI和分子向疗法 (MTT) 队列.
- 在ICI队列中,T2DM患者的PFS中位数明显较差,但在MTT队列中没有.
- 没有观察到不良事件的显著差异;然而,较高的HbA1c与dNLR升高相关. 专家咨询改善了ICI队列中的PFS.
结论:
- T2DM是高级NSCLC患者的独立不良预后因素.
- T2DM显著影响免疫检查点抑制剂 (ICI) 治疗在晚期NSCLC中的疗效.
- 专家咨询是改善ICI治疗的T2DM患者治疗结果的潜在因素.
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