哺乳期的持续时间和全身性青少年形性关节炎的风险:一个横截面研究
Qiang Luo1, Hui Zhang1, Xinlin Wu1
1Department of Rheumatology and Immunology, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Frontiers in nutrition
|September 15, 2025
概括
较短的母乳养时间与系统性青少年异常性关节炎 (sJIA) 的风险增加有关. 像中性粒细胞数和CRP这样的炎症标志物部分解释了这种关联,这表明早期营养对疾病发展有影响.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 系统性青少年异常性关节炎 (SJIA) 是一种具有独特免疫路径的自身炎症性疾病.
- 早期营养,就像母乳养一样,可能会影响免疫发育和炎症疾病风险.
- 关于母乳养在sJIA发展中的作用的数据有限.
研究的目的:
- 调查母乳养时间与sJIA与非sJIA发展的可能性之间的关联.
- 确定系统性炎症标志物是否调解了母乳养和SJIA之间的关系.
- 了解早期营养暴露对自身炎症性疾病风险的影响.
主要方法:
- 对450名患有JIA的儿童进行横截面研究.
- 追溯收集母乳养时间数据.
- 多变量逻辑回归和受限制的立方螺纹模型来分析关联.
- 调解分析以量化炎症标志物的作用.
主要成果:
- 与非sJIA患者 (n=300,9.1个月) 相比,sJIA患者 (n=150) 的母乳养时间明显较短 (6.3个月).
- 较短的母乳养独立地与较高的sJIA几率相关 (aOR=0.86).
- 中性细胞计数,白细胞计数和CRP部分介导了母乳养与SJIA的联系 (26.5%,25.8%,12.4%的效果).
结论:
- 减少母乳养时间与发展sJIA的可能性增加有关.
- 系统性炎症部分介导了母乳养和SJIA之间的关联.
- 研究结果表明,早期营养会影响自身炎症性疾病的表现,这需要进一步的研究.
更多相关视频
相关概念视频
Teratogenicity
4.0K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.0K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
644
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
644
The JAK-STAT Signaling Pathway
12.1K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
12.1K
Development of Immunocompetence
793
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
793
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
500
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
500
Drug Dosing: Infants and Children
256
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
256


