恶性瘤患者的加密球菌内炎:病例报告和文献综述
Kamonchanok Phaopraphat1, Rujipas Sirijatuphat1
1Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Medical mycology case reports
|September 15, 2025
概括
罕见的真菌眼部感染Cryptococcal endophthalmitis发生在一个肺癌患者身上. 随着系统性和静脉内抗真菌药物的迅速治疗,她的视力得到了显著改善.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 加密球菌内炎是一种不常见但严重的眼部并发症 *Cryptococcus neoformans*感染.
- 它主要影响免疫受损的个体,经常出现视觉障碍.
研究的目的:
- 在患有晚期肺癌的患者中报告一种罕见的加密球菌内炎病例.
- 描述所采用的诊断方法和多模式治疗策略.
主要方法:
- 一名50岁的女性患有转移性肺癌,视力模糊.
- 诊断部分平面玻璃切除术证实了玻璃体中的*Cryptococcus neoformans*.
- 治疗涉及全身 (安福特素B,流动素,流可纳) 和静脉内 (安福特素B,伏利可纳) 抗真菌剂.
主要成果:
- 患者的视觉敏度从2英尺的指数改善到3/60的指数,针孔校正到6/18.
- 这种视力恢复是在经过10个月的综合抗真菌治疗后实现的.
- 在随访期间没有发现复发.
结论:
- 加密球菌内炎可能发生在癌症患者中,需要积极的联合治疗.
- 通过玻璃切除术早期诊断和及时启动全身和局部抗真菌治疗对于视觉保存至关重要.
- 多种模式的抗真菌治疗为免疫功能低下的主体的加密球菌内炎提供了有利的预后.
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