在麻疹,艾滋病毒和SARS-CoV-2感染中心率变异性发生变化;微妙的自主参与 - 试点研究
Ilinca Savulescu-Fiedler1, Teodora Deaconu2, Roxana Siliste1
1MD, PhD, Department of Internal Medicine, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474, Bucharest, and Department of Internal Medicine, Coltea Clinical Hospital, Bucharest, 030167, Romania.
炎症可以影响自主功能,降低心率变化率 (HRV). 这项研究发现,麻疹和艾滋病毒患者的HRV较低,但在COVID-19中反应更稳定,将炎症与麻疹和艾滋病毒中的同情主导联系起来.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 神经学 神经学
背景情况:
- 炎症与dysautonomia有关,其特点是心率变化降低 (HRV).
- 像SARS-CoV-2,麻疹和艾滋病毒这样的RNA病毒感染可以影响自主神经系统功能.
- 了解病毒感染中的HRV变化对于评估疾病影响和恢复至关重要.
研究的目的:
- 为了比较急性 (SARS-CoV-2,麻疹) 和慢性 (HIV) RNA病毒感染的患者之间的HRV参数.
- 研究这些病毒感染中HRV和炎症标志物之间的关联.
- 探索与病毒感染的类型和慢性性相关的自主反应的差异.
主要方法:
- 评估了25名病毒感染患者 (麻疹,COVID-19,艾滋病毒) 和8名对照.
- 在标准化条件下,在时间和光谱领域评估HRV.
- 与炎症标志物相关的HRV参数,包括血清纤维素原.
主要成果:
- 与对照组和COVID-19患者相比,在麻疹和艾滋病毒患者中观察到显著下降的HRV参数 (SDNN,rMSSD).
- COVID-19患者的HRV值最高,表明自主反应更加稳定.
- 在麻疹和艾滋病毒中发现了LF/HF比率和血清纤维素素之间的相关性,这表明与炎症相关的同情主导地位.
结论:
- 麻疹和艾滋病毒感染与HRV显著下降有关,这表明disautonomia.
- 与麻疹和艾滋病毒相比,轻度至中度的COVID-19形式显示出更稳定的自主反应.
- 炎症与麻疹和艾滋病毒中的同情主导标记相关,但在COVID-19中没有,因此需要进一步调查.
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