疑似利拉格卢提德 (葡萄糖类-1受体激动剂) 诱导的甲状腺功能过高症:一个病例报告
Siti Nur Syakinah Md Sabudin1, Lili Husniati Yaacob2, Muhammad Rahmat Che Omar3
1MBBS, MMed (Family Medicine), Medical and Basic Dental Sciences Unit, School of Dental Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
概括
利拉格卢提德是一种GLP-1RA,很少会导致甲状腺功能障碍. 一个案例研究表明,一名34岁的妇女在使用利拉格卢提德减肥后患上甲状腺功能障碍,在停止服用药物后恢复.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 利拉格卢提德是一种类似葡萄糖类-1受体激动剂 (GLP-1 RA),是用于体重管理和血糖控制的常见治疗方法.
- 虽然GLP-1RA通常是安全的,但可能会引起不良反应,甲状腺功能障碍很罕见.
研究的目的:
- 报告一种罕见的新发型甲状腺功能障碍病例,该病例发生在患者中,该患者正在使用利拉格卢提德减肥.
- 讨论利拉格卢提德诱导的甲状腺功能障碍的潜在机制和临床影响.
主要方法:
- 一个34岁的妇女在开始服用利拉格卢提德后出现甲状腺功能过高的症状的病例报告.
- 进行了临床检查,实验室甲状腺功能测试 (TSH,自由T4) 和甲状腺受体抗体测试.
- 立拉古类药物已停止使用,患者接受了碳醇和醇的治疗.
主要成果:
- 患者患有甲状腺功能障碍,TSH受抑制,自由T4水平升高,对Graves病呈阴性.
- 症状消失,甲状腺功能在停止服用利拉格卢提德后的几周内恢复正常.
- 在liraglutide使用和甲状腺功能障碍的出现之间观察到强烈的时间关联.
结论:
- 利拉格卢提德的使用可能与罕见的甲状腺功能障碍的病例有关,正如在本案中所示.
- 由GLP-1RA引起的甲状腺功能障碍的潜在机制需要进一步研究.
- 建议在GLP-1RA的症状患者中保持警并考虑对甲状腺功能进行监测.
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