结直肠横向扩散瘤的亚粘膜透的病理特征和危险因素
Wen-Jie Shi1, Jian-Bo Han1, Gong-Ming Cheng1
1Department of General Surgery, The Second Hospital of Nanjing, Nanjing 210000, Jiangsu Province, China.
World journal of gastrointestinal surgery
|September 15, 2025
概括
确定结直肠横向扩散瘤 (LST) 的危险因素有助于治疗. 大尺寸,直肠位置和特定类型 (LST-NG-PD) 增加癌症风险和亚粘膜入侵,指导内镜切除选择.
科学领域:
- 胃肠病学 胃肠病学
- 内視鏡外科手術 內視鏡外科手術
- 在瘤学瘤学.
背景情况:
- 横向扩散瘤 (LSTs) 具有独特的内镜和病理特征.
- 了解LST癌症的致癌和底透的风险因素对于有效的管理至关重要.
研究的目的:
- 为了分析结肠直肠LSTs的临床病理特征进行内镜治疗.
- 在LST中确定致癌和下粘膜入侵的风险因素.
- 为最佳的内镜治疗策略提供基于证据的指导.
主要方法:
- 对422名结直肠LST患者进行内镜治疗的回顾性分析 (2021年1月 - 2024年7月).
- 评估患者的人口统计,病变特征和治疗方式 (ESD,EMR).
- 统计分析包括单变量和多变量逻辑回归来确定风险因素.
主要成果:
- 致癌的关键风险因素包括病变大小 (>2厘米),直肠位置和特定的内镜分类 (LST-NG-PD,LST-G均,LST-G结节混合) 与大结节.
- 鉴定了下膜透的独立风险因素,如LST-NG-PD分类和大结节的存在.
- 病理发现包括各种等级的瘤,7.5%的下侵袭性癌症.
结论:
- 具有大结节的LST-NG-PD等特定风险因素表明优先考虑内镜下膜解剖 (ESD).
- 超过2厘米的高风险直肠病变可能需要在内镜切除之前进行进一步的成像.
- 这些发现支持根据已识别的风险因素为结直肠LST量身定制的治疗策略.
更多相关视频
相关概念视频
02:30Metastasis
6.4K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.4K
02:07Tumor Progression
7.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.2K
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
903
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
903